Correlation of serum vitamin D levels with serum levels of alkaline phosphatase.

  • Momina Haq Peshawar Medical College,
  • Farzana Salman Peshawar Medical College,
  • Mohsina Haq Peshawar Medical College,
  • Seher Obaid Peshawar Medical College,
  • Ambreen Gul Peshawar Medical College,
  • Arbab Muhammad Kashif Khan Peshawar Medical College,
Keywords: Chronic hepatitis C patients, Serum vitamin D levels, Serum alkaline phosphatase

Abstract

Objectives: To determine whether serum vitamin D levels are correlated with serum levels of alkaline phosphatase or not? Study Design: Case control cross sectional study. Setting: Gastroenterology unit of private teaching hospital in Peshawar. Period: From November 2015-Januaray 2016. Material and Methods: 100 participants meeting the criteria were included in the study. Fifty clinically normal young adults and fifty were non cirrhotic chronic hepatitis C patients were included in the study. Venous blood samples were taken from all the study participants and serum vitamin D levels were determined by Electro-chemiluminescence binding assay (ECLIA) and serum alkaline phosphatase was determined by Photometric Kinetics. Results: patients were divided into two groups on the basis of gender i.e.25 males and 25 females. A correlation between vitamin D and alkaline phosphatase was determined. Alkaline phosphatase was raised in the non cirrhotic chronic hepatitis C patients. Pearson correlation was applied to find out the relation between vitamin D levels and alkaline phosphatase in the two groups which had a significant relationship with a p-value of 0.01. A positive correlation between alkaline phosphatase and parathyroid hormone was found with a p value of <0.0001. Conclusion: In our study alkaline phosphate was considerably increased in chronic hepatitis C patients who might be due to underlying liver disease. In chronic liver disease the hepatocytes swell up and due to damage to the liver parenchyma the level of alkaline phosphatase increases.

Author Biographies

Momina Haq, Peshawar Medical College,

MBBS, M-Phil (Physiology)

Assistant Professor

Department of Physiology

 

Farzana Salman, Peshawar Medical College,

MBBS, M-Phil (Physiology)

Associate Professor

Department of Physiology

 

Mohsina Haq, Peshawar Medical College,

MBBS, M-Phil (Microbiology)

Assistant Professor

Department of Microbiology

 

Seher Obaid, Peshawar Medical College,

MBBS, M-Phil (Physiology)

Assistant Professor

Department of Physiology

 

Ambreen Gul, Peshawar Medical College,

MBBS, M-Phil (Chemical pathology)

Assistant Professor

Department of Pathology

 

Arbab Muhammad Kashif Khan, Peshawar Medical College,

MBBS, FCPS Part-I

 

Published
2019-10-10