PARACETAMOL OVERDOSE;

ROLE OF TRIFOLIUM EXTRACTS ON THE LIVER FUNCTIONS OF PARACETAMOL OVERDOSE IN RABBITS.

  • Muhammad Asif Gajju Khan Medical College, Swabi.
  • Abdul Haq Wazir Nowshera Medical College, Nowshera.
  • Tayaba Basharat Nowshera Medical College, Nowshera.
  • Masood Uz Zaman Gajju Khan Medical College, Swabi.
  • Shabir Hussain Bannu Medical College, Bannu.
  • shafqat ullah
  • Amir Hamza Bannu Medical College, Bannu.
Keywords: Paracetamol,, Trifloium flower extracts,, AST,, ALT,, ALP,, T.bilrubin

Abstract

Background: Liver plays a central role in the process of metabolism, storage of glycogen and detoxification. It acts as major organ in the physiologic role of body. Paracetomol is oftenly used as a pain reliever and antipyretic, its overdose can liver toxicity and produces free radicals which is dangerous for human health. Objectives: To find the role of trifolium extract in the limitation of hepatotoxicity instigate by paracetamol overdose. Study Design: _____________. Setting: Pathology Department, Post Graduate Medical Institute (PGMI) Lahore. Period:  April 2016 to October 2016 for the period of 6 months. Material and Methods: Total 32 rabbits were taken for the study. They were divided into four groups. Group I was control, group II, III, IV were intoxicated with paracetamol dose 1, 1.5, 2 g/kg body weight respectively. Each group was composed of 8 rabbits. Each paracetamol intoxicated rabbit was treated with triflolim extract for 5 days. Results: Paracetamol overdose causes a significant raise in the liver functions eg alanine aminotransferase (ALT), Asparate aminotransfearse (AST) alkaline phosphatase (ALP) and total bilirubin (T. bilrubin). There is remarkable improvement in the liver functions when the intoxicated rabbits were treated with triflolium extract. Conclusion: Triflolium extracts has better results and can limits the damaging effects of paracetamol overdose on liver functions.

Author Biographies

Muhammad Asif, Gajju Khan Medical College, Swabi.

MBBS, M.Phil (Pathology),
Associate Professor
Department of Pathology

Abdul Haq Wazir, Nowshera Medical College, Nowshera.

DMJ
Assistant Professor
Department of Forensic Medicine

Tayaba Basharat, Nowshera Medical College, Nowshera.

M.Phil Pharmacology
Assistant Professor

Masood Uz Zaman, Gajju Khan Medical College, Swabi.

DMJ
Associate Professor
Department of Forensic Medicine

Shabir Hussain, Bannu Medical College, Bannu.

M.Phil Pharmacology
Assistant Professor

shafqat ullah

MBBS, MPH

 

Amir Hamza, Bannu Medical College, Bannu.

MBBS, DMJ
Assistant Professor
Department of Forensic Medicine

Published
2019-05-10