HISTAMINE RECEPTORS

RESPONSES AND MODULATIONS TOWARDS AGONIST AND ANTAGONIST ON THE RABBIT ILEUM, IN VITRO STUDY

Authors

  • AFTAB TURABI Islam Medical College, Sialkot
  • GHULAM ALI ASGHAR QURESHI Islam Medical College, Sialkot
  • Muhammad ZIAULLAH Rehman Medical Institute, Hayattabad, Peshawar
  • S. Saud Hasan Dow Medical College, Dow University of Health Sciences, Karachi

DOI:

https://doi.org/10.29309/TPMJ/2010.17.04.3026

Keywords:

H (histamine), G.I. (gastrointestinal), IP3 (inositol tri phosphate), 5-HT (5-hydroxytryptamine), AMP (cyclic amino mono phosphate), Ca (calcium)

Abstract

Objective: This research work deals with the mechanism of action involved in determining the therapeutic potential of histamine and its blockers in gastrointestinal motility. Study Design: Rabbits of equal weights were used in this study. They were brought from the animal house of BMSI, sacrificed in the Pharmacology Research laboratory. Ileum strip were isolated and with special recommended methodology, longitudinal and circular muscles were separated. Individual muscle strip were then exposed separately to the desired drugs in the organ bath and reading were recorded on the polygraph machine. Setting: Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. Period: 1996 to 1998. Results: Histamine increases the contractile effects of longitudinal and circular muscle. H and H blockers 1 2 potentiate its effects on longitudinal muscle while in circular muscle no change was observed with H blocker whereas H blocker antagonized 1 2 the histaminic effects. However when H blocker applied directly it increases the amplitude of contraction in longitudinal and circular muscle 1 whereas H blocker decreases the height of contractions. Histamine in the presence of H and H blocker augmented their effects in longitudinal 2 1 2
muscle and antagonizes in circular layer. Conclusion: Gastrointestinal motility can be controlled through histamine and its antagonist. New drugs can be formulated on the basis of this study for the regulation of intestinal motility. 

Author Biographies

AFTAB TURABI, Islam Medical College, Sialkot

MBBS, M. Phil, Ph.D., Post doc. (USA)

Professor and Head Department of Pharmacology & Therapeutics

GHULAM ALI ASGHAR QURESHI, Islam Medical College, Sialkot

MBBS, MPH (UK), MSPH (USA)

Associate Professor and Head Department of Community Medicine

Muhammad ZIAULLAH, Rehman Medical Institute, Hayattabad, Peshawar

MBBS, FCPS

Associate Professor

Department of Pathology

S. Saud Hasan, Dow Medical College, Dow University of Health Sciences, Karachi

MBBS, M. Phil

Associate Professor and Head

Department of Pharmacology & Therapeutics

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Published

2010-12-10