ANAL FISSURE;

TREATMENT WITH GLYCERYL TRINITRATE (FIVE YEARS EXPERIENCE)

Abstract

Objective: To evaluate the efficacy of glyceryl trinitrate (GTN) preparation for the treatment fissure in-ano. Design: This study
is a prospective clinical trial. Place and duration: this was conducted initially at PMC Faisalabad and other centers from November 2001 to
onward for the period of five years. Patients and Methods: Out of 306 patients, 42 disliked/ refused this modality of treatment and was
launched on 264 patients. 114 patients never followed up so, were excluded from the study. The remaining 276 patients applied 0.2% glyceryl
trinitrate preparation on their anal verge thrice a day for two months. The patients were followed up at 1 to 12 weeks. The extent of st th
improvement in the presenting symptoms, side effects and complications were noted on questionnaires. Results: A healing rate of 64.3%, and
recurrence occurred in 35.7 %. 72 patients demanded surgery after failure/ non-compliance of GTN ointment treatment. Conclusion: glyceryl
trinitrate preparation is a safe and effective modality for the treatment of fissure in-ano.