Analysis of effects of acid suppression therapy on renal tissue using experimental animal.

  • Shoaib Ahmed Rai Medical College, Sargodha.
  • Farwa Naqvi Sargodha Medical College, Sargodha.
  • Nadeem Yaqoob Niazi Medical and Dental College, Sargodha.
  • Bilal Habib Rai Medical College, Sargodha.
  • Nadir Ali Rana Sargodha Medical College, Sargodha
  • Rao Salman Aziz Rashid Latif Medical College, Lahore.
  • Amal Shukat University of Sargodha Sargodha.
  • Farah Naz Akbar University of Sargodha Sargodha.
  • Faiqa Chaudhury Sargodha Medical College Sargodha University of Sargodha Sargodha.
  • Hassan Makhdoom Sargodha Medical College Sargodha University of Sargodha Sargodha.
Keywords: Cellular Infiltrate, Congestion, Renal Toxicity, Acid Suppression Therapy

Abstract

Objectives: To analyze the effects of acid suppression therapy by proton pump inhibitors on renal tissue by using mice as experimental animal. Study Design: Randomized control trial. Setting: Animal house of University of Sargodha. Period: 6 weeks (From 1st January 2018 to 15th February 2018). Material and Methods: The sample consisted of 60 mice. Simple Random Sampling was the technique which was used for the sampling procedure. The mice were procured from Veterinary University Lahore Punjab. The animals were handled according to the international standards of environmental and ethical conditions. The animals were divided into three groups. One group was labeled as control group for comparison and the other groups served as experimental. The histological study was done to analyze the effects of proton pump inhibitors. Results: Histological analysis of the sections made from the renal tissue revealed that acid suppression therapy given in the form of proton pump inhibitors induced toxic effects on the kidneys. The glomerulus was observed to be congested along with cellular infiltrate in the interstitium.

Author Biographies

Shoaib Ahmed, Rai Medical College, Sargodha.

MBBS, M.Phil (Biochemistry)

Assistant Professor

Department of Biochemistry

Farwa Naqvi, Sargodha Medical College, Sargodha.

MBBS, M.Phil (Pharmacology)

Assistant Professor

Department of Pharmacology

 

Nadeem Yaqoob, Niazi Medical and Dental College, Sargodha.

MBBS, M.Phil (Pharmacology)

Assistant Professor

Department of Pharmacology

 

Bilal Habib, Rai Medical College, Sargodha.

MBBS, M.Phil (Physiology)

Assistant Professor

Department of Physiology

 

Nadir Ali Rana, Sargodha Medical College, Sargodha

MBBS M.Phil Forensic Medicine (UK)

Assistant Professor

Department of Forensic Medicine

 

Rao Salman Aziz, Rashid Latif Medical College, Lahore.

MBBS, M.Phil (Pharmacology)

Assistant Professor

Department of Pharmacology

 

Amal Shukat, University of Sargodha Sargodha.

M.Phil Nutrition,

Department of Food and Nutrition

 

Farah Naz Akbar, University of Sargodha Sargodha.

M.Phil Nutrition,

Department of Food and Nutrition

Faiqa Chaudhury, Sargodha Medical College Sargodha University of Sargodha Sargodha.

M.Phil Food and Technology,

 

Hassan Makhdoom, Sargodha Medical College Sargodha University of Sargodha Sargodha.

MBBS, RIU ISL

Lecturer

 

Published
2019-11-10