PROPOFOL INDUCED PAIN;

COMPARISON BETWEEN EFFECTS OF LIDOCAINEPROPOFOL MIXTURE AND METOCLOPRAMIDE PREMEDICATION

Abstract

Introduction: Propofol causes pain on injection in 28% - 90% of
patients. A number of techniques have been tried for minimizing propofol-induced pain with variable results.Objectives:
To compare the use of premixed lidocaine-propofol with metoclopramide pretreatment for the reduction of pain during
injection of propofol in adult patients. Design: A prospective, double blind, randomized, placebo-controlled study.
Setting: Shiraz University Hospital, Department of Anesthesiology, Shiraz, Iran. Period: From Jan 2007 to Dec 2007.
Materials & Methods: 202 subjects (ASA I-II) scheduled for elective operations under general anesthesia were
allocated into three groups and treated as follows: Group A: 20 ml propofol mixed with 20mg lidocaine %1 following 2ml
normal saline; Group B: 20 ml propofol mixed with 2ml normal saline following 5 mg metoclopramide; Group C (control
group): 20 ml propofol mixed with 2 ml normal saline following 2 ml normal saline. Pain intensity was graded by a single,
blinded observer and recorded as either severe, moderate, mild or no pain according to the response of the patients
to the injection. Results: The incidence of pain was 72% in placebo group compared to 58.7% in the metoclopramide
and 28.8% in the lidocaine group. Conclusion: Propofol-lidocaine admixture is more effective than metoclopramide
pre treatment in decreasing the pain of propofol injection.