VITAMIN D3 DEFICIENCY;

VITAMIN D3 DEFICIENCY AND INSUFFICIENCY IN CLINICALLY ASYMPTOMATIC AND APPARENTLY HEALTHY YOUNG ADULTS.

Abstract

Objectives: Determination of vitamin D₃ deficiency and insufficiency in clinically asymptomatic and apparently healthy young adult male. Study Design: Cross sectional study. Study setting & Duration: Department of Medicine, Layari General Hospital Shaheed Muhtrama Benazir Bhutto Medical College from March 2015 to May 2016.Subjects and Methods: A sample of 100 volunteer participants, comprising of 57 male and female was selected according to the study criteria. 5 ml venous blood was collected in disposable syringe. Blood urea, serum creatinine, serum calcium and phosphate were estimated by standard laboratory procedures. ARCHITECT I 1000 system detected the vitamin D₃. Data analysis was analysed by SPSS 22.0 (USA). Results: Serum Calcium and Phosphate were noted as 8.76±1.11 and 9.20±0.2 mg/dl (P=0.036) & 3.23±0.85 and 3.25±0.80 mg/dl (P=0.71) in male and female subjects respectively. Vitamin D₃ (mean± SD) in male and female was noted as 23.0±8.24 and 27.19±14.13 ng/dl (P=0.006). Vitamin D₃ (mean± SD) of total study population was noted as 24.80± 11.29 ng/ml. Frequency of vitamin D₃ deficiency, insufficiency and sufficiency noted in 45%, 32% and 23% respectively (P=0.0001). Conclusion: We found vitamin D₃ deficiency and insufficiency in 77% of young apparently healthy and clinically asymptomatic adults