COLORECTAL CANCER

OVERALLS URVIVAL AND ITS PROGNOSTIC FACTORS , A RETROSPECTIVE ANALYSIS FROM 10 YEAR DATA FORM JHL

Abstract

There is paucity of data on epidemiology and survival in colorectal cancer from developing countries. O b j e c t i v e s : To determine
overall survival and its predictive factors. S e t t i n g : Department of Oncology Jinnah Hospital Lahore. P e r i o d : From July 1997 to Dec
2007.Methods: 73 patients were analyzed. Patient demographic data including age, sex, socio-economic status, pre-treatment CEA levels,
Duke's stage, site of tumor (colon, rectum) and complete tumor resectability were recorded. Univariate analysis by chi-square and multivariate
analysis were performed by Cox Regression Model to evaluate the predictors of survival. SPSS v 13.0 was used for statistical analysis. Kaplan-
Meier estimate was used to calculate survival. R e s u l t s : Median age of our patients was 45 years. Male to female ratio was 1:1.2. Complete
surgical resection could be performed in only 48 (68.5%) patients. Majority (70%) patients had Duke C and D. Overall survivals at 36 months
was 53 % and was 90% for Duke A and B, while it was 61% and 26% for Duke's C and D respectively. Females had a better survival rate of
74% as compared to males with a survival of 36%. Patients with proximal colon tumors had survival of 73% as compared to 37% in rectal/rectosigmoidgroup. Patients with high pre-treatment CEA had poor survival 39%. Only 25% patients with unresectable tumors were alive at 36
months compared to 67% in patients with resectable tumors. Conclusion: Significant predictive factors for improved survival were female gender,
early disease, patients with proximal colon tumors, low pre-treatment CEA levels and complete tumor resection.