CHRONIC HEPATITIS C VIRUS;

DERMATOLOGICAL MANIFESTATIONS OF INTERFERON PLUS RIBAVIRIN THERAPY IN PATIENTS

Abstract

Objective: To determine the frequency and pattern of dermatological manifestations
in patients receiving interferon and ribavarin for hepatitis C. Patients & Methods: The study
was conducted in the Dermatology out patients department (OPD) of Dow University Hospital
Karachi from April –November 2013.Patients diagnosed with hepatitis C who received interferon
a(3 MIU subcutaneously thrice weekly) plus ribavirin (1200 mg daily for 24 weeks).Detailed
history and dermatological examination including mucous membrane,hair and nails was
performed initially and then monthly for six months and findings were recorded. Results: A
total of 109 patients were included in the study.Frequency of various skin diseases in these
patients werepruritis 44(40.36%), transient alopecia 14(12.84%),generalized morbiliform rash
in 22 (20.18%),photosensitivity in 8(7.33%), secondary hyperpigmentation in 17(15.59%)
patients.Lichen Planus was observed in 6 (5.50%) patients while brittle nails were seen in 5
(4.58%), glossitis in 4(3.66%),chelitis in 8(7.33%)and generalized exfoliating dermatitis in
9(8.25%) patients.Apthous ulceration was observed in 7 (6.42%) patients. Conclusions: HCV
and its treatment with interferon plus ribavirin is associated with significant dermatological
complications. Physicians should be aware of these side effects and patients should be
counseled before starting treatment.