Diagnostic accuracy of perfusion weighted MRI in differentiating neoplastic and non-neoplastic brain lesions using histopathology as Gold standard.

  • Abdul Raouf Allied Hospital, Faisalabad.
  • Anem Mahboob Allied Hospital, Faisalabad.
  • Tajawar Gul Allied Hospital, Faisalabad.
  • Muhammad Ahsan Allied hospital Faisalabad.
Keywords: Neoplastic Brain Lesions, Non-Neoplastic Brain Lesions, PW-MRI


Objectives: Perfusion-weighted imaging may be performed as a complementary examination to conventional MRI techniques. The clinical applications of PWI in the evaluation of focal brain lesions include the differentiation between neoplastic and non-neoplastic brain lesions, primary tumors and solitary metastasis and, in the post-treatment follow up, the differentiation of tumoral recurrence and radio necrosis. To determine the diagnostic accuracy of perfusion weighted MRI in differentiating. Neoplastic and non-neoplastic brain lesions keeping histopathology as gold standard. Study Design: Cross sectional (validation) study. Setting: The study was conducted in Radiology department of Allied Hospital Faisalabad. Period: Six months from 25-March-2016 to 24-Sep-2016. Material and Methods: Permission for this study was taken from the hospital ethical review committee. A total of 125 patients were included and MRI examination was performed with the patients in supine position using a 1.5-T Philips MRI unit and a body phased-array coil. A preload of paramagnetic contrast agent (gadolinium) was administered 30 seconds before acquisition of dynamic images, followed by a standard dose 10 seconds after starting imaging acquisitions. Results: Patients ranged between 15-65 years of age. Mean age of the patients was 47.6±10.6 years. There were 65 males (52%) and 60 females (48%). PW MRI showed sensitivity 81.67%, specificity 81.54%, positive predictive value 80.33%, negative predictive value 82.81% and diagnostic accuracy 81.60%. ROC and likelihood ratio was measured for age and gender. For age (15-40 years) likelihood ratio was 7.187 and for age 41-65 likelihood ratio was 48.665. For males likelihood ratio was 31.759 while for females 16.188. Conclusion: In conclusion, our results suggest a promising role for perfusion MR imaging in the distinction between neoplastic and non-neoplastic lesions.

Author Biographies

Abdul Raouf, Allied Hospital, Faisalabad.


Fellowship of Intervention Radiology

AKU, Karachi.

Senior Registrar


Anem Mahboob, Allied Hospital, Faisalabad.


Medical Officer

Department of Radiology

Tajawar Gul, Allied Hospital, Faisalabad.


House Officer

Muhammad Ahsan, Allied hospital Faisalabad.


Medical Officer