ANALGESIC EFFICACY;

COMPARISON OF KETOROLAC AND DICLOFENAC SODIUM

Abstract

Aim: To compare the analgesic efficacy of a single dose preoperative intramuscular Ketorolac versus diclofenac sodium for
prevention of postoperative pain after third molar surgery. Design: This Experimental comparative study. Setting: Department of Anesthesia,
Pakistan Atomic Energy Commission, Al-Zahra Hospital, Geo Care, and Maryam Maternity Hospital, DG Khan. Period: October 2011 to March
2012. Material and Method: Patients undergoing elective third molar surgery were randomly assigned into one of the two groups. In each
group, 60 patients completed the study properly. Group-I received diclofenac sodium 75 mg IM 20 min preoperatively and group-II received
Ketorolac 30 mg IM 20 min preoperatively. Result: Patient in Ketorolac group reported significantly lesser pain intensity scores in the 3rd hour
pain than the Diclofenac group (p-value lesser than 0.0001). Patient also reported significantly longer mean time to rescue analgesic 7.5 h
versus 4.8h (p lesser than 0.001., student t test) that is approximately 2.5 h longer duration of preventive analgesic consumption (p=0.006,
student t test). Conclusions: Preoperative intramuscular injection of Ketorolac 30 mg is more effective than Diclofenac 75 mg in the prevention
of post operative 3rd molar pain.