EFFECTS OF CINNAMON EXTRACT IN DIABETIC RAT MODELS IN COMPARISON WITH ORAL HYPOGLYCEMIC DRUGS

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Authors

  • Muhammad Sajid Khan Al Tibri Medical College, Karachi
  • Aneela Qureshi Al Tibri Medical College, Karachi
  • Shuja Anwar Kazi Al Tibri Medical College, Karachi
  • Amin Fahim Al Tibri Medical College, Karachi
  • Husan Bano Al Tibri Medical College, Karachi
  • Navaid Kazi Isra University Hyderabad
  • Asghar Khan Isra University Hyderabad
  • Mazhar ul Haque Al Tibri Medical College, Karachi

DOI:

https://doi.org/10.29309/TPMJ/2014.21.04.2425

Keywords:

Cinnamon extract, Serum glucose, Diabetes

Abstract

Objective: To evaluate the anti diabetic effect of cinnamon extract in alloxan
induced diabetic animal model (albino rats) in comparison with oral hypoglycemic drugs. Study
Design: An Experimental study. Place of Study: Al Tibri Medical College, Isra University, Karachi
Campus. Duration of Study: December 2012 to December 2013. Materials and Methods: Total
60 Albino rats of both genders were divided into 6 groups consisting of 10 rats in each group.
Each group of animals was further divided into two sub groups containing 5 rats in each group
Results: The results obtained from the data indicated that there is significant reduction in blood
glucose level rats treated with low dose of cinnamon extract. The animals of low dose cinnamon
extract (200mg/kg. bw) when compared with other groups; there is a reduction in the blood
glucose level in alloxan induced diabetic rats. Also tolbutamide and acarbose treated groups
showed better antidiabetic effects as compared with cinnamon extract treated groups (p
value<0.007 and p value<0.012 respectively), but cinnamon extract treated group showed
synergetic effects when it was given in combination with tolbutamide or acarbose having
significant p value<0.001 and p value<0.011 respectively. Conclusions: Tolbutamide and
Acarbose showed better anti diabetic effect in comparison with cinnamon extract treated groups
when used individually. This effect was enhanced when cinnamon was used in combination with
either tolbutamide or acarbose.

Author Biographies

Muhammad Sajid Khan, Al Tibri Medical College, Karachi

Department of Physiology

Aneela Qureshi, Al Tibri Medical College, Karachi

Department of Pathology,

Shuja Anwar Kazi, Al Tibri Medical College, Karachi

Department of Physiology,

Amin Fahim, Al Tibri Medical College, Karachi

Department of Pathology

Husan Bano, Al Tibri Medical College, Karachi

5. Department of Physiology,

Navaid Kazi, Isra University Hyderabad

6. Department of Physiology,

Asghar Khan, Isra University Hyderabad

Department of Pathology

Mazhar ul Haque, Al Tibri Medical College, Karachi

8. Department of Anatomy

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Published

2018-12-07