RELATIONSHIP OF BRAIN NATRIURETIC PEPTIDE WITH SERUM LIPIDS AND BODY MASS INDEX IN HEALTHY ADULT MALES

Abstract

Prevalence of morbid obesity has increased dramatically world wide during past three decades. BNP a cardiac lipolytic hormone is found to be decreased in obese hypertensive and heart failure patients. Increasing values of BMI are associated with dyslipidemia. Objective: To find out the relationship of BNP with increasing values of BMI and individual serum lipid fractions in apparently healthy adult males. Study Design: Observational, cross-sectional study. Setting: Department of Physiology at Basic Medical Sciences Institute, Jinnah Post Graduate Medical Center, Karachi. Material & Methods: Study included 85 adult males, aged between 20-60 years. All were nonsmokers, non- diabetic, having no other chronic illness and not taking any lipid lowering therapy. Study participants were evaluated for lipid profile and divided into three groups for the calculated BMI values according to WHO and International Obesity Task Force. Brain Natriuretic
Peptide was assayed by AxSym technology. Results: Brain Natriuretic Peptide developed a negative correlation with BMI, total and LDLcholesterol and a positive relation with HDL-cholesterol and triglycerides. Conclusions: This study concluded that Brain Natriuretic Peptide is negatively related with increasing values of BMI and degree of dyslipidemia in apparently healthy adult males.