Relationship between serum vitamin D and insulin resistance in normal weight and overweight or obese men.

  • Sabiha Iqbal Central Park Medical College, Lahore.
  • Syed Imran Ali Shah Central Park Medical College, Lahore.
  • Mirza Zeeshan Sikandar Central Park Medical College, Lahore.
Keywords: Insulin Resistance, Obesity, Vitamin D, Glucose Intolerance

Abstract

Obesity is a common clinical disorder featuring excessive buildup of body fat. The bioavailability of vitamin D in obese subjects is lowered because of its sequestration in the superfluous fat tissue. Hypovitaminosis D itself is associated with glucose intolerance, insulin resistance, dyslipidemia and hypertension, which are also linked to obesity. Objectives: To compare and correlate serum vitamin D and insulin resistance in controls and overweight / obese males. Study Design: Cross Sectional, Comparative Study. Setting: The study was conducted in the Department of Physiology, Post – Graduate Medical Institute (PGMI) in collaboration with Lahore General Hospital and Central Park Medical College. Period: From 7th June 2018 to 10th Oct 2018. Material and Methods: Eighty male subjects (age range 35-50 years) included in this cross-sectional comparative study were divided into two groups on the basis of BMI; Group I: non-obese (control) BMI < 25 Kg/m2 (n=40) and Group II: overweight / obese males with BMI ˃25 Kg/m2 (n=40). Fasting serum vitamin D (25 hydroxy cholecalciferol; 25-OH D, serum insulin and blood glucose levels were measured. Insulin resistance (IR) was estimated from fasting serum glucose levels taken in mmol/l and the fasting serum insulin taken in µIU/ml by using Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR index). Results: Group II had lower serum 25-OH vitamin D levels and higher HOMA-IR index than control group. Significant negative correlation was present between serum vitamin D and HOMA-IR. Conclusion: Vitamin D deficiency may promote insulin resistance in overweight or obese individuals.

Author Biographies

Sabiha Iqbal, Central Park Medical College, Lahore.

MBBS, M.Phil

Assistant Professor

Department of Physiology

Syed Imran Ali Shah, Central Park Medical College, Lahore.

MBBS, M.Phil, DIC, PhD

Head

Department of Biochemistry

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Mirza Zeeshan Sikandar, Central Park Medical College, Lahore.

MBBS Student

Department of Biochemistry

 

Published
2019-11-10