METHANOLIC EXTRACT

HEPATOPROTECTIVE EFFECT OF METHANOLIC EXTRACT

Abstract

Purpose of Study: The aim of this study is to look at the plant based such compounds that are known to have hepatoprotective
potential. With above perspective, the study has been planned to see the hepatoprotective potential. To see hepatoprotective effect on the
enzyme levels and histopathology. With the help of this study, some new hepatoprotective compound may be discovered which will help in
developing an effective medicine. Material & Methods: The extract of Melia azedarch’s flower was screened for hepato protective effect. Albino
rats were administered with carbon tetra chloride (CCl4) for inducing liver damage. Results: The effect of the extract was evaluated by
measuring the liver enzymes like SGPT, Alkaline Phosphatase, Bilirubin and Gamma-GT in the serum. In the extract treated animals, there was
significant decrease in liver enzyme levels. This observation leads to the conclusion that Melia flower extract possesses hepato protective
activity. The hepato protective activity of the methanolic extract was compared with standard Poly herbal formulation named Jigrine CL.
Conclusion: In our study, we found the extract of Melia Azedarach (Flowers) has strong hepatoprotective activity.