CHRONIC HYPERTENSION

ASSESSMENT OF HAEMOSTATIC PARAMETER CHANGES

Abstract

Background: Hypertension is an important risk factor for cardiovascular morbidity and mortality. Myocardial infarction, and
strokes, which are complications of hypertension, predominantly occur due to thrombosis of arterioles leading to ischemia and infarcts. NO
suppression leads to hypertension associated with haemostatic changes that may endanger life. Material and methods: Rats were randomly
divided into 2 groups equal in number, each contain 20 rats. Group (A) a control group given distillate water and Group (B) hypertension induced
group receiving NG-nitro-L-arginine methyl ester (L-NAME) for induction of hypertension. Results: Group 2 showed significant increases of mean
blood pressure, plasma fibrinogen levels, significant reduction in mean values of percentages of platelets aggregation, significant increase in
mean values of Plasminogen Activator Inhibitor-1 Antigen (PAI-1 antigen), significant increase in mean values of thromin-antithrombin complex
(TAT)) and significant increase in mean values of soluble glycoprotein V (sGPV). In contrast, platelets counts showed insignificant changes
in its mean values. Conclusion: The present study demonstrates, the increase in plasma fibrinogen levels, fibrinolysis activities as indicated
by increase in plasminogen Activator lnhibitor-1 Antigen (PAI-1 antigen), and systemic plasma thrombin which is detected by increases of mean
plasma levels of thromin-antithrombin complex (TAT)) and soluble glycoprotein V (sGPV). Meanwhile decrease in nitric oxide in chronic
hypertension produces slight decrease in platelets count and aggregation.