THYROID SWELLINGS

CYTOPATHOLOGICAL STUDY OF THYROID SWELLINGS BY FINE-NEEDLE ASPIRATION CYTOLOGY

  • Nazeer Ahmed Pathan Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Sindh, Pakistan.
  • Abdul Aziz Shaikh Liaquat University of Medical and Health Sciences Jamshoro, Sindh, Pakistan.
  • Abdul Aziz Shaikh Liaquat University of Medical and Health Sciences Jamshoro, Sindh, Pakistan.
  • Manzoor Ali Shaikh Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Sindh, Pakistan.
Keywords: Cytopathology, FNAC, Histopathology, Thyroid Swellings

Abstract

Objectives: Investigating cytopathological characteristics of thyroid swellings
by fine-needle aspiration cytology (FNAC) compared to histopathological examination. Study
Design: Observational study. Place and Duration: Department of Pathology in collaboration
with Department of Surgery, Liaquat University of Medical and Health Sciences from November
2014 to December 2016. Methods: A sample of 100 FNAC specimens was selected as per
inclusion and exclusion criteria. FNAC procedure was conducted by technique of “to and
fro movements” of needle for thyroid nodules of <1.5 cm size from central part of swelling.
Peripheral part was aspirated in cases of large thyroid swellings. Smears were air dried and
stained with May–Grunwald Giemsa (MGG) and H & E stain for histopathological examination
by microscopy. Data was analyzed on SPSS 22.0 at 95% confidence interval (p≤0.05). Results:
Mean± SD age was noted as 47.6±8.6 years. Of total 200 cases, male and female were 90 (45%)
& 110 (55%) respectively. Benign thyroid lesions were noted in 140 (70%), malignant thyroid
lesions in 50 (25%) and 10 (5%) proved indeterminate thyroid lesions. FNAC shows sensitivity
of 89%, specificity 97% and accuracy of 91%. Conclusion: FNAC is an easy, time escaping,
cost- effective, simple procedure and valid technique for the triage of thyroid swellings.

Author Biographies

Nazeer Ahmed Pathan, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Sindh, Pakistan.

MBBS, M.Phil
Associate Professor Pathology

Abdul Aziz Shaikh, Liaquat University of Medical and Health Sciences Jamshoro, Sindh, Pakistan.

MBBS, M.Phil
Assistant Professor Pathology

Abdul Aziz Shaikh, Liaquat University of Medical and Health Sciences Jamshoro, Sindh, Pakistan.

MBBS, M.Phil
Assistant Professor Pathology

Manzoor Ali Shaikh, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Sindh, Pakistan.

MBBS, M.Phil
Assistant Professor Pathology

Published
2018-10-10