PANCYTOPENIA;

STUDY FOR CLINICAL FEATURES AND ETIOLOGICAL PATTERN AT TERTIARY CARE SETTINGS IN ABBOTTABAD

Authors

  • Atif Sitwat Hayat Isra University Hospital, Hala Road Hyderabad, Sind, Pakistan
  • Abdul Haque Khan Liaquat University of Medical and Health Sciences Jamshoro, Sind, Pakistan
  • Ghulam Hussian Baloch Liaquat University of Medical and Health Sciences Jamshoro, Sind, Pakistan.
  • Naila Shaikh Liaquat University of Medical and Health Sciences Jamshoro, Sind, Pakistan.

DOI:

https://doi.org/10.29309/TPMJ/2014.21.01.1790

Keywords:

Pancytopenia,, aplastic anemia, general practitioners, quacks,, bone marrow examination.

Abstract

Background: Pancytopenia is an important hematological problem encountered
in our day-to-day clinical practice. The aim of our study was to evaluate clinical features and
etiological pattern of pancytopenia at tertiary care settings in Abbottabad. Methods: This
prospective study was conducted at Northern Institue of Medical Sciences (NIMS) and Ayub
Teaching Hospital Abbottabad from 25th August 2009 to 31st July 2010. A total of 85 patients
fulfilling the criteria of pancytopenia were randomly selected by time-based sampling.
Pancytopenia was diagnosed by anemia (hemoglobin ≤ 10.0g/dl), leucopenia (WBC ≤ 4.0×109/L)
and thrombocytopenia (platelets ≤ 150×109/L). All data has been entered and analyzed by SPSS
version 10.0. Results: Out of 85 patients, 62(72.94%) were males and 23(27.05%) females with
M to F ratio of 2.69:1. The mean age (±SD) of males was 30.20±15.42 years, while that of females
35.12±16.31 years (p=0.20). Among clinical features, anemia and generalized weakness were
the commonest (97.64%), followed by shortness of breath (88.23%). Majority 54(63.52%) had
non-malignant disorders responsible for pancytopenia. Overall, the most common cause of
pancytopenia was aplastic anemia noted in 30(35.29%) cases, followed by megaloblastic anemia
15(17.64%) and hypersplenism in 13(15.29%). Conclusions: On conclusion, aplastic anemia
was the most common cause of pancytopenia in our study predominantly affecting young adult
males. It

Author Biographies

Atif Sitwat Hayat, Isra University Hospital, Hala Road Hyderabad, Sind, Pakistan

MBBS, M.D (Medicine)
Assistant Professor of Medicine

Abdul Haque Khan, Liaquat University of Medical and Health Sciences Jamshoro, Sind, Pakistan

MBBS, FCPS (Medicine)
Associate Professor of Medicine

Ghulam Hussian Baloch, Liaquat University of Medical and Health Sciences Jamshoro, Sind, Pakistan.

MBBS, Dip Card, M.D (Medicine)
Associate Professor of Medicine

Naila Shaikh, Liaquat University of Medical and Health Sciences Jamshoro, Sind, Pakistan.

MBBS, DCP
Senior Lecturer,

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Published

2014-02-10