DRUG INDUCED HEPATITIS

DOES HEPATITIS B AND HEPATITIS C CO-INFECTION INCREASES THE RISK DURING ANTI TUBERCULOUS CHEMOTHERAPY

Authors

  • Shuaib Ansari Liaquat University of Medical & Health Sciences, Jamshoro/Hyderabad
  • Muhammad Adnan Bawany Isra University Hospital, Hyderabad Sindh Pakistan
  • Atif Sitwat Hayat Isra University Hospital, Hyderabad Sindh Pakistan.
  • Akram Munir Liaquat University of Medical & Health
  • Adnan Ali Khahro Hyderabad Sindh Pakistan.
  • Falak Naz Isra University Hospital, Hyderabad Sindh Pakistan.

DOI:

https://doi.org/10.29309/TPMJ/2014.21.01.1787

Keywords:

Hepatitis B,, Hepatitis C,, drug induced hepatitis

Abstract

Aims and Objectives: We evaluated whether HBV +ve and HCV +ve patients are
at high risk for developing drug induced hepatitis than control subjects during treatment for
tuberculosis with standard short course regimens. Study design: Observational cohort study.
Place and duration: This study was conducted at Department of Medicine, Liaquat University of
Medical and Health Sciences Jamshoro from May 2008 to May 2011. Material and Methods: All
newly diagnosed active tuberculosis patients were included in the study population and they
were further screened for hepatitis B surface antigen and HCV antibodies. All patients were
divided into three groups. One having no co-infection with hepatitis B and Hepatitis C and was
taken as control group, second group was co-infected with hepatitis B and third was co-infected
with hepatitis C. short course anti tuberculous regimen was started and patients were followed for
six months. Results: One hundred and twenty eight tuberculous patients were divided into three
groups. 92 in control groups without any co-infection with hepatitis B and C, 10 were HBV +ve
and 26 were HCV +ve. During follow up 24 developed drug induced hepatitis, 8(38.33%, n = 24)
in control group, 2(8.33%, n = 24) in hepatitis B group and 14(58.33%, n = 24) in hepatitis C
group. Conclusions: These findings suggest that treatment for tuberculosis in HCV seropositive
patients is a risk factor for the development of hepatitis exacerbation and HBV seropositive
patients shows no any increased risk of hepatitis exacerbation.

Author Biographies

Shuaib Ansari, Liaquat University of Medical & Health Sciences, Jamshoro/Hyderabad

FCPS (Medicine), Associate Professor

Muhammad Adnan Bawany, Isra University Hospital, Hyderabad Sindh Pakistan

MBBS, FCPS (Medicine),
Assistant Professor

Atif Sitwat Hayat, Isra University Hospital, Hyderabad Sindh Pakistan.

MBBS, MD (Medicine),
Assistant Professor

Akram Munir, Liaquat University of Medical & Health

FCPS (Medicine),
Senior Medical Officer,

Adnan Ali Khahro, Hyderabad Sindh Pakistan.

MBBS, Isra University Hospital,

Falak Naz, Isra University Hospital, Hyderabad Sindh Pakistan.

MBBS, 

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Published

2014-02-10