IN VITRO FERTILIZATION

IMPACT OF AMH AND FSH LEVELS ON IVF AND SUCCESS RATE A PROSPECTIVE ANALYTIC STUDY FROM LIFE CLINIC LAHORE PAKISTAN

Abstract

Various ovarian reserve tests were developed to estimate the ovarian reserve and
predict about the outcome in subfertile females undergoing evaluation for assisted reproduction.
FSH and AMH levels are considered to be good ovarian reserve indicators along with antral
follicle count. Objectives: To explore relationship of AMH and FSH in patients undergoing IVF
with respect to ovarian reserve and outcome of the treatment. Study Design: Prospective cohort.
Study Period: 1st January 2015 to 31st December 2015. Place of study: Lahore Institute of
Fertility and Endocrinology, Hameed Latif Hospital, Lahore Material and Methods: In 346 IVF/
ICSI patients after anthropometric measurements and transvaginal ultrasound antral follicle
count were assessed in each ovary. For the hormone measurements blood samples were taken
during the early follicular phase of menstrual cycle. Clinical pregnancy was also visualized
through transvaginal ultrasound. Results: From the 346 IVF/ICSI patients 89 (25.79%) clinical
pregnancies resulted. The mean age in pregnant group was 32.89 ± 2.99 years and in nonpregnant
group was 33.62 ±4.36. Mean FSH and AMH in pregnant group was 6.38 ±2.38,
3.27 ±1.86 and in non- pregnant group was 7.54±3.76, 2.72 ± 1.82 respectively. Age and
FSH are significantly associated with each other (p-vale = 0.000) and mostly patients had FSH
below 9(mIU/mL). Age and AMH are significantly associated with each other (p-vale = 0.000)
and mostly patients had AMH above 1.5 (ng/mL). Conclusions: Better pregnancy rate was
associated with FSH below than 9 (mIU/mL) and AMH above 1.5 (ng/mL).