HEPATITIS “C”

FREQUENCY OF HEPATIC STEATOSIS IN NON RESPONDER PATIENTS

Abstract

Objectives: To determine incidence of steatosis in non-responder cases
of chronic HCV. Study Design: Cross-sectional study. Setting: Tertiary Care Sanatorium in
Medicine Department of LIAQUAT University Hospital Hyderabad/Jamshoro. Period: 26-9-2011
to 25 August 2012. Material & Methods: Total 144 non-responders cases of Hepatitis C were
integrated. Both gender, age 18 to 50 yrs, chronic HCV non-responder cases as well as cases fit
for hepatic biopsy were integrated in study. Grading of Inflammation was carried out as indicated
by histopathological measures. Results: Mean age was 48.5 + 5.2years. Uppermost prevalence
of chronic HCV disease was 65(45.13%) at 41 to 50 years age interval whereas 42(29.1%) cases
were noticed in 31 to 40 yrs age group and 25(17.3%) cases were observed in 20 to 30 years
of young age group. In this study hepatic steatosis occurrence was observed in 103 (71.5%)
cases and these were categories as: grade 1, grade 2, grade 3, as (<33%) 45/103(43.68%), (33
to 66%) 35/103(33.98%), (>66%) 23/103(22.33%) respectively. Conclusion: Hepatic steatosis
is a important risk factor the cases of HCV to decreased response to antiviral therapy and for
progression toward fibrosis as observed in cases related to metabolic steatosis.