CHRONIC KIDNEY DISEASE

THE ASSOCIATION OF PLATELET COUNT WITH ESTIMATED GLOMERULAR FILTRATION RATE IN KNOWN CASES

Authors

  • Shagufta Memon Isra University, Hyderabad
  • Navaid kazi Isra University, Hyderabad
  • Amin Fahim Al-Tibri Medical College, Karachi
  • Ghulam Shah Nizamani Isra University, Hyderabad
  • Anila Qureshi Al-Tibri Medical College, Karachi

DOI:

https://doi.org/10.29309/TPMJ/2016.23.07.1639

Keywords:

platelet count, Glomerular filtration rate, chronic renal failure

Abstract

Objectives: This study aimed to determine the platelet count in diagnosed
chronic renal failure patients and to find out the association of platelet count with glomerular
filtration rate. Study Design: Case control study. Place of study: Diagnostic and research
laboratory Liaquat University Hospital Hyderabad and Nephrology Unit, Isra University Hospital
Hyderabad. Duration of study: January 2015 to July 2015. Materials and methods: Total of
one hundred and twenty subjects (n=120) were divided into two groups. The healthy controls
(n=60) were included in group-I whereas patients with chronic renal failure (n=60) were kept in
group-II. 5 ml of blood was drawn and sent to laboratory for estimation of serum platelet count,
blood urea nitrogen and serum creatinine levels. Results: The present study showed highly
significant difference with marked decrease in the platelet counts seen in the CRF patients
with 223.9±89.1 million/μL in comparison to the 347.60±55.9 million/μl platelets in control
individuals. Also the results of BUN in CRF patients showed highly significant differences with
27.67±7.68 mg/dl when compared to controls having BUN 8.95±1.02 mg/dl. The comparison
between GFR with mean platelet count showed negative correlation (r = -0.27) in CRF patients.
Conclusion: The present study shows weak negative correlation of platelet count with GFR.

Author Biographies

Shagufta Memon, Isra University, Hyderabad

Department of Physiology,

Navaid kazi, Isra University, Hyderabad

Department of Physiology,

Amin Fahim, Al-Tibri Medical College, Karachi

Department of Pathology,

Ghulam Shah Nizamani, Isra University, Hyderabad

Department of Physiology,

Anila Qureshi, Al-Tibri Medical College, Karachi

Department of Pathology,

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Published

2016-07-10