TYPE 2 DIABETICS

EVALUATING SERUM COBALAMIN WITH SPECIAL REFERENCE TO DYSLIPIDEMIA

Abstract

Objectives: To evaluate serum cobalamin with special reference to dyslipidemia
in type 2 Diabetic subjects. Study Design: Observational study Place and Duration:
Department of Medicine, Isra University Hyderabad, Sindh from January 2014 to July 2014.
Methodology: A sample of 107 type 2 diabetic subjects was selected according to inclusion
and exclusion criteria. Cobalamin was measured on Roche Cobas e411 chemistry analyzer
and blood lipoproteins by standard laboratory methods. Data was analyzed by SPSS 21.0
(IBM, Incorporation, USA) using student t and Chi square tests for continuous and categorical
variables respectively. P-value of ≤ 0.05 was taken significant. Results: Cobalamin deficiency
was noted in 51 (47.6%) of diabetics and cobalamin deficiency was associated with
dyslipidemia. Mean ± SD of cobalamin in normal and reduced cobalamin groups were noted
as 355±29.5 and 183±17.5 pg/ml respectively (p=0.0001). Triglycerides, total cholesterol,
HDLc, LDLc and VLDLc differed significantly in the normal and reduced cobalamin subjects
(p<0.001). Lipoprotein sub fractions showed a negative correlation with serum cobalamin
(p≤0.02). Conclusion: Cobalamin deficiency is common in type 2 diabetics and is associated
with dyslipidemia.