BLADDER CARCINOMA;

MICRO-RNAS: EXPRESSION OF MIR-145 IN PATIENTS, AS A NEW DIAGNOSTIC APPROACH

Abstract

Objectives: To determine the micro-RNA-145 expression in bladder cancer
patients when compared with controls and clinicopathological parameters. Study design: A
case control study. Place of Study: Samples were collected from Jinnah Postgraduate Medical
Center Karachi and Civil Hospital Karachi. Duration of Study: January 2014 to December
2014. Materials and Methods: Total of 180 patients of bladder carcinoma were divided into
three groups according to WHO/1998 classification system. PUNLMP in group-I, PUCLG in
group-II, PUCHG in group-III were compared with 60 healthy controls in group-IV. Results:
The results showed that miR-145 expression was decreased in patients with bladder cancer
when compared with controls. Down regulation was more obvious in BC cases with increasing
grade. A significant correlation was found between the expression of miR-145 with microscopic
hematuria, cystoscopy and staging. Whereas no association was found with age, frequency,
urgency, flank pain, gross hematuria, urine pH, and ultrasound. Conclusion: miR-145 is down
regulated in BC patients with significant correlation with microscopic hematuria, cystoscopy
and staging.