DIABETIC NEPHROPATHY

EFFECTS OF GINGER EXTRACT ON SERUM CREATININE AND PAIRED KIDNEY WEIGHT IN ALLOXAN INDUCED DIABETIC NEPHROPATHY OF ALBINO RATS

Authors

  • Faiza Irshad Islam Medical & Dental College Sialkot.
  • Rabia Sajjad Toor Sahara Medical College, Narowal.
  • Madiha Hussain Post Graduate Medical Institute, Lahore.

DOI:

https://doi.org/10.29309/TPMJ/2018.25.07.156

Keywords:

Diabetes Mellitus, Kidney, Diabetic Nephropathy, Ginger, Alloxan

Abstract

Background: Zingiber Officinale Roscoe (Zingiberaceae family) is known
as Ginger. It is famous for its antioxidant properties. Objectives: To evaluate the effects of
Ginger aqueous extract on the serum creatinine and paired kidney weight in Alloxan induced
diabetic nephropathy of albino rats. Study Design: Experimental study. Period: 06 months
01-01-2013 to 30 June 2013. Setting: Anatomy Department, Sheikh Zayed, PGMI Lahore.
Materials and Methods: Diabetes mellitus was induced with Alloxan intraperitoneally (150 mg/
kg body weight) in Experimental groups B & C. Then the rats of experimental group C received
200mg/kg body weight of ginger aqueous extract by gavage daily for five weeks starting from
8th day after Alloxan injection. Results: Serum creatinine levels increased more in experimental
group B as compared to experimental group C. Group wise comparison of creatinine level
revealed that the difference among control (A group) and experimental (B & C Groups) was
significant having p-value <0.001. We observed that Paired kidney weight in experimental
group B increased as compared to control group A. Less increase in the paired kidney weight
was observed in experimental group C as compared to experimental group B. The difference
of mean paired kidney weight among three groups was significant having p-value <0.001.
Conclusion: The results of the present study indicated that the co-treatment of Ginger aqueous
extract prevented alloxan induced diabetic nephropathy in albino rats. The aqueous extract of
Ginger showed amazing results on paired kidney weight.

Author Biographies

Faiza Irshad, Islam Medical & Dental College Sialkot.

MBBS, M.Phil (Anatomy)
Assistant Professor
Department of Anatomy

Rabia Sajjad Toor, Sahara Medical College, Narowal.

MBBS
Senior Demonstrator
Department of Anatomy

Madiha Hussain, Post Graduate Medical Institute, Lahore.

M.Phil Student
Department of Anatomy

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Published

2018-07-10