CURCUMA LONGA

CURCUMA LONGA AGAINST CARBON TETRACHLORIDE INDUCED LIVER INJURY: A BIOCHEMICAL AND HISTOPATHOLOGICAL EXPERIMENTAL STUDY

Authors

  • Sana Naz Suleman Roshan Medical College, Tando Adam, Sindh, Pakistan
  • Faisal Irshad Bhitai Dental and Medical College Mirpurkhas, Sindh, Pakistan
  • Hina Mawani Tando Muhammad Khan, Sindh, Pakistan

DOI:

https://doi.org/10.29309/TPMJ/2018.25.07.154

Keywords:

Carbon Tetrachloride, Liver Injury, Curcuma Longa, Rat

Abstract

Objectives: To analyze the hepatoprotective effects of Curcuma longa (CL)
against carbon tetrachloride (CCl4) induced chemical injury in experimental rats. Study Design:
Experimental study. Setting: Indus Medical College in collaboration with Animal house of Sindh
Agriculture University Tando Jam. Period: March 2016 to August 2016. Methodology: Sixty
adult male rats were selected according to inclusion and exclusion criteria. Rats were divided
randomly into 3 groups – as group A. controls, group B – received CCl4 and group C- received
CCl4 + CL orally. Blood samples were taken after 4 weeks of therapy by cardiac puncture.
5μ thick liver tissue sections were stained for light microscopy examination. Analysis of data
was performed on Statistix 9.0 (USA) at statistical significance of p-value ≤ 0.5. Results: Liver
cell biochemical markers of injury and histopathological examination show the Curcuma longa
is effective against carbon tetrachloride induced liver injury (P <0.05). Liver histology was
improved by the curcuma longa therapy. Conclusion: Liver aminotransferase and histology
were improved significantly by the curcuma longa therapy in carbon tetrachloride induced liver
injury.

Author Biographies

Sana Naz, Suleman Roshan Medical College, Tando Adam, Sindh, Pakistan

MBBS, M.Phil
Associate Professor
Department of Anatomy

Faisal Irshad, Bhitai Dental and Medical College Mirpurkhas, Sindh, Pakistan

MBBS, M.Phil
Assistant Professor
Department of Pathology

Hina Mawani, Tando Muhammad Khan, Sindh, Pakistan

MBBS, M.Phil
Assistant Professor
Department of Anatomy
Indus Medical College

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Published

2018-07-10