ALLIUM SATIVUM ESSENTIAL OIL (ASEO);

EFFECT OF SUPPLEMENTATION ON SERUM TRIGLYCERIDES, TOTAL CHOLESTEROL, HDLC, LDLC AND BLOOD CELL COUNTS IN ALBINO RATS

Abstract

Objectives: To determine the effects of Allium sativum essential oil (ASEO)
phytotherapy on serum triglycerides, total cholesterol, HDLc, LDLc and blood cell counts in
albino rat model. Study design: Experimental study. Setting and Duration: Animal House,
Sindh Agriculture University and Isra University Hyderabad from May 2014 to January 2015.
Materials and Methods: 60 albino rats were divided into four groups. Controls were given
Placebo. Experimental rat groups were given ASEO 100 mg/kg, 200 mg/kg and 300 mg/kg
orally for 30 days. Cardiac puncture was performed for blood sampling. Research variables
were analyzed on Statistix 10.0 (USA). Results: Blood lipids showed significant reduction in
various blood lipid fractions. Serum LDLc exhibited with a concomitant rise in serum HDLc (p
=0.0001) in high ASEO treated rats. Red blood cells, white blood cells and platelet showed
significant improvement ASEO fed rats (p=0.001). Conclusion: Allium sativum essential oil
(ASEO) phytotherapy showed a rise in HDLc and a reduction in LDLc, triglycerides and total
cholesterol with improvement in red blood cell counts.