ISCHEMIC HEART DISEASES

HOMOCYSTEINE LEVEL IN PATIENTS

Abstract

Objectives: To determine the frequency of hyperhomocysteinemia level in
patients with ischemic heart diseases. Study Design: Case series study. Setting: Liaquat
University Hospital Hyderabad. Period: Six months. Patients and Methods: All the patients
with known ischemic heart disease of either sex gave the history of myocardial infarction and
echocardiography showed motion wall abnormalities were recruited and entered in the study.
After confirmation of IHD, the 2cc venous blood sample was taken in sterilize disposable
syringe and sent to laboratory for evaluation of serum homocysteine levels while the data was
collected on pre-designed proforma and the data was analyzed in SPSS 16 and the frequency
and percentage was calculated. Results: Total one hundred patients with known ischemic
cardiac disease were recruited and evaluated for homocysteine level. The mean ±SD for
age of patients with ischemic heart diseases was 55.82±10.94. Majority of the patients were
males 57% and the male to female cross tabulation was statistically significant (p=0.02). The
hyperhomocysteinemia was not statistically significant in relation to age while it is significant
in relation to gender (p=0.01). The overall frequency of hyperhomocysteinemia in IHD was
62% with male predominance 66%, of sixty percent hyperhomocysteinemic individuals 41.9%
had severe, 37.1% had intermediate and 21% had mild elevated homocysteine level (p=0.02).
Conclusion: It was concluded that hyperhomocysteinemia was associated