VACCINATED HEMODIALYSIS PATIENTS

THE STATUS OF IMMUNITY AGAINST THE HEPATITIS B VIRUS, AT A TERTIARY CARE HOSPITAL

Authors

  • Ahsan Mobin Dow University Hospital
  • Fawed Qureshi Dow University Hospital OJHA Campus Karachi
  • Muhammad Umar Khan Dow University Hospital OJHA Campus Karachi
  • Rakhshinda Jabeen Dow University Hospital Karachi

DOI:

https://doi.org/10.29309/TPMJ/2016.23.04.1495

Keywords:

Hemodialysis, Hepatitis B, Immunity, Vaccination

Abstract

Objectives: Determine the status of immunity against the hepatitis B virus among
vaccinated hemodialysis patients at a tertiary care hospital. Study Design: Cross sectional
study. Place and Duration of Study: All medical wards of Civil Hospital and Ojha campus, Dow
University of Health Sciences, Karachi, Pakistan from May 2013 to January 2015. Methodology:
Patients with chronic kidney disease on hemodialysis attending out-patient department were
enrolled. Patients with either gender and aged 18-70 years, who give consent for participation,
who are on HD for more than 9 months with a proven diagnosis of ESRD who have received
a complete course of 4 doses of hepatitis B vaccination atleast 2 months back were included
in this study. Non-consenting patients, present/past history of viral hepatitis, patients who
were hepatitis B surface antigen (HBsAg) positive, patients on immunosuppressive agents,
pregnant patients were excluded from this study. Results: Out of the 103 patients, 69 (67%)
males and 34 (33%) females with mean age of study population was 51.1 ± 14.3 years (17 to
70 years), mean duration post vaccination was 7.6 ± 0.9 months (6 to 9 months), mean anti
HBs antibody level was 184.6 ± 293.4 (level rang 0 to 1000) and mean hemodialysis duration
was 26.4 ± 12 months (10 to 50 month). Out of 37 non-responders 28 (75.7%) had twice weekly
schedule of hemodialysis and 09 (24.3%) had thrice weekly schedule of hemodialysis, out of 19
weak responders 13 (68.4%) had twice weekly schedule of hemodialysis and 06 (31.6%) had
thrice weekly schedule of hemodialysis and out of 47 high responders 29 (61.7%) had twice
weekly schedule of hemodialysis and 18 (38.3%) had thrice weekly schedule of hemodialysis
(p=0.395). Conclusion: Excellent response of HbsAg B vaccination for those patients, undergo
dialysis procedure that is not associated with age, systemic inflammation or nutritional. Effective
dialysis procedure associated with excellent response to the vaccine hepatitis B.

Author Biographies

Ahsan Mobin, Dow University Hospital

MBBS, FCPS
Assistant Professor of Medicine

Fawed Qureshi, Dow University Hospital OJHA Campus Karachi

MBBS, FCPS
Assistant Professor of Medicine

Muhammad Umar Khan, Dow University Hospital OJHA Campus Karachi

MBBS, FCPS
Assistant Professor of Medicine

Rakhshinda Jabeen, Dow University Hospital Karachi

MBBS, FCPS
Assistant Professor of Medicine

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Published

2016-04-10