DIABETIC NEPHROPATHY

PROTEIN TO CREATININE RATIO AS A COST EFFECTIVE DIAGNOSTIC TOOL FOR DETECTION

Authors

  • Hassan Bukhari Allied Hospital Faisalabad
  • Asim Shaukat Allied Hospital Faisalabad
  • Amir Hayyat Mahes Allied Hospital Faisalabad

DOI:

https://doi.org/10.29309/TPMJ/2016.23.03.1478

Keywords:

Diabetic Nephropathy, PC Ratio, Albuminuria

Abstract

Objectives: To determine diagnostic accuracy of spot urine Protein to creatinine
ratio for detection of diabetic nephropathy taking 24-hour urinary protein as gold standard.
Study Design: cross sectional. Settings: Medical and Radiology department of Allied hospital
Faisalabad. Duration: 12-12-2013 to 12-06-2014. Sample size: 134. Material & Methods: It
was a cross-sectional study done in Medical Unit I, Allied Hospital Faisalabad. 134 patients with
suspicion of diabetic nephropathy were included. 24-hour urine sample collected by instructing
patients to begin collection immediately after completion of first voiding in morning and to
collect all urine into same container having 5mL of 10% thymol in iso-propanol as a preservative
for 24-hours. This was thoroughly mixed, 2mL was taken for evaluation of proteins. P.C ratio
was calculated by dividing Urinary Protein concentration by Urinary Creatinine concentration.
Results: The mean age of patients was noted as 55.11±6.79 years. There were 62.7% male
and 37.3% female patients. Mean PC ratio of the patients was noted as 0.21±0.07. Sensitivity
of PC ratio was noted as 95.2%, whereas specificity was 76.5%, PPV 86.8%, NPV 90.7% with
diagnostic accuracy of 88.1%. Conclusion: The study results showed that PC

Author Biographies

Hassan Bukhari, Allied Hospital Faisalabad

Department of Radiology,

Asim Shaukat, Allied Hospital Faisalabad

Department of Radiology,

Amir Hayyat Mahes, Allied Hospital Faisalabad

Department of Radiology,

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Published

2016-03-10