• Khalida Naz Memon Liaquat University of Medical & Health Sciences, Jamshoro.
  • Aneela Atta Ur Rahman Public Health Sciences, LUMHS, Jamshoro.



Consanguinity,, total inbreeding,, birth outcome,, intrauterine death.


Introduction: The epidemiological literature is inconsistent in its findings on
association of parental consanguinity & birth outcomes. Research studies rarely look into the
kin relationship of the spouses as a possible risk factor for reproductive wastage including
intra uterine deaths (IUDs). Objective: To assess the effect of parental consanguinity on birth
outcome of the offspring. Data Source & Study Setting: Hospital based study carried out in
maternity wards of public sector & private hospitals in Hyderabad. Study Design: Comparative
cross sectional. Study Period: Eight months. Material & Methods: Data was collected on nine
hundred & sixty two new borne by filling up of questionnaire & taking notes from maternity history
sheets; the intrauterine death for the current pregnancy was the outcome variable of interest
& for better appraisal of the effect of consanguinity on offspring mortality, logistic regression
was applied on selected proximate determinants separately for each group of consanguinity.
Results: Higher rate of IUD was observed among consanguineous couples as compared to
comparison group (12.86% v/s 2.93%). Strongly significant association of IUDs for the current
pregnancy was reported among consanguineous parents, second cousins & totally inbred
offspring i.e. (OR 4.89; 95% CI 2.61, 9.15; p=0.00), (OR 2.13; 95% CI 1.22, 3.72; p= 0.007) &
(OR 5.07; 95% CI 3.18, 8.06; p=0.00) respectively; whereas first cousin & uncle-niece relation
of spouses revealed insignificant results. Conclusions: Consanguinity is a critical predictor of
intrauterine deaths among offspring’s. At the policy level, there is need for educating people
about the offspring’s’ health risks associated with consanguineous marriages.

Author Biographies

Khalida Naz Memon, Liaquat University of Medical & Health Sciences, Jamshoro.

Associate Professor.
Department of Community

Aneela Atta Ur Rahman, Public Health Sciences, LUMHS, Jamshoro.

Dean F/O Community Medicine &