SCLEROSING EPITHELIOID FIBROSARCOMA

A CASE REPORT AND REVIEW OF LITERATURE

Abstract

Sclerosing epithelioid fibrosarcoma (SEF) is a rare subtype of Fibrosarcoma
and was first reported in 1995. This tumour is rarely encountered and can easily be mistaken by
clinicians for other diagnoses. This paper reports one case of SEF and review related literature.
Objectives: To determine the clinical pathologic characteristics and discuss differential
diagnosis of sclerosing epithelioid fibrosarcoma (SEF). Methods: One case of SEF was studied
by clinical analysis, light microscopy and the review of the literature. Results: The patient was
an adult and had a tumor located in the subcutaneous tissue of the left leg, which was
painless and grew slowly. Macroscopically, it was described as nodular and non-encapsulated.
The cut section was gray-white, firm to elastic in consistency. The microscopic examination
showed that the round to ovoid epithelioid cells with clear or eosinophilic cytoplasm arranged
in cords, nests, sheets or alveolar pattern. The stroma showed a dense hyalinized collagenous
background. Conclusions: Sclerosing epithelioid fibrosarcoma is a low-grade variant of
fibrosarcoma, histologically, it should be differentiated from a variety of tumors which have the
epithelioid appearance and sclerosing stroma.