SURGICAL SITE INFECTION

IN-VITRO ANTI-BACTERIAL ACTIVITY OF DIFFERENT BRANDS OF CEFTRIAXONE AGAINST BACTERIA COMMONLY IMPLICATED IN SURGICAL SITE INFECTION AND THEIR COST EFFECTIVENESS

Abstract

Ceftriaxone is used in wide range of day to day microbial infections in clinical
practice3. Despite the incumbent drug regulating authority in Pakistan, there is scanty literature
comparing the anti-microbial efficacy of different available brands of ceftriaxone. Objectives:
To know the in-vitro activity of various brands of ceftriaxone against bacteria most commonly
isolated from surgical site infection (SSI). A comparison of five days cost of these brands will
also be done. Design: Experimental study. Period: Feb 2013 to Aug 2013 Setting: Surgical
“C” unit Lady Reading Hospital (LRH) in collaboration with departments of pharmacology
Khyber Girls Medical College (KGMC) and microbiology department of Lady Reading Hospital
Peshawar. Material & Methods: Isolates of five bacteria i.e. Staphylococcus aureus, Proteus
mirabilis, Escherischia coli, enterobacter Spp, and Klebsiella pneumoniae, found sensitive to
ceftriaxone were grown on 50 slops each and the zone of inhibition was checked for each of
the ten brands of ceftriaxone. Results: The zones of inhibitions of different brands of ceftriaxone
against the above mentioned bacteria were not significantly different. The cost of therapy was
significantly different for ten brands. Conclusions: Various brands of ceftriaxone of variable
cost had no influence on their activity against bacteria involved in SSI.