HAEMANGIOPERICYTOMA

CLINICOPATHOLOGICAL ANALYSIS OF CENTRAL NERVOUS SYSTEM

Abstract

Hemangiopericytoma (HPC) in central nervous system is a rare tumor, his tumor
has a high recurrence rate and the characteristics of extracranial metastases. Objectives:
To investigate the clinicopathological features, imaging features, immunohistochemical
phenotype of haemangiopericytoma (HPC) of central nervous system. Design: Hospital based
crossectional prospective study. Period: From 24th October to 26th October 2012. Setting: First
People’s Hospital of Jining City, China. Methods: The clinical manifestations, imaging features,
histopathological and immunohistochemical features were analyzed combining the review of the
literature in one case of central HPC. Results: The Gross examination revealed the size of the
tumor was 5cm × 4cm× 1.5cm; the section is gray, medium soft texture, and part of the area had
capsule. The microscopic examination showed that the tumor cells were abundant and the same
size, showing round, oval or short spindle shape. The cytoplasm was eosinophilic, and part of
it was slightly translucent. The nuclei were ovoid, and the nucleoli were inconspicuous.A lot of
capillaries lined by endothelial cells were seen in the tumor tissue, and the blood vessels were
dilated like “staghorn” in some areas. Immunohistochemistry showed that tumor cells expressed
Vimentin, CD34, CD99, Bcl-2, PR protein. They didn’t express EMA, SMA, and S-100 protein.
The proliferation index of ki-67 is about 4%. Conclusions: The central haemangiopericytoma
is a rare tumor, having no specific clinical manifestations and imaging features. The final
diagnosis requires a combination of histopathological and immunohistochemical examination,
and it should be differentiated from meningioma, solitary fibrous tumor, hemangioblastoma and
mesenchymal chondrosarcoma, etc.