HEPATITIS C

EARLY PREDICTION OF THERAPY RESPONSE IN PATIENTS AND THE BENEFITS OF TREATMENT EXTENSION IN NON RESPONDERS

Abstract

Hepatitis C virus (HCV) has infected about 200 million individuals across the
world and is known as the major cause of liver disease . Objectives: Viral load measurement
at early stages of the therapy in Hepatitis C patients is believed to be a more effective tool
to predict the sustained virological response (SVR). The primary aim of the present study
was to evaluate whether the decline in viral load of HCV at early stages of the therapy may
predict the treatment response. Another objective was to see the benefits of therapy extension
in non-responders. Study Design: Descriptive, analytical study. Setting: Shalamar Hospital
Lahore. Period: November 2010 to October 2013. Methods: Four hundred and thirty patients,
chronically infected with different genotypes of Hepatitis C virus were treated with Interferon
alpha 2b plus Ribavirin (IFNα-2b + RBV). Viral load was assessed at day zero, week four, in
the mid time of therapy and at the end of therapy. The treatment duration was extended 12-24
weeks (according to HCV genotypes) in non-responders. Results: The patients with <2 MIU/
mL viral load at day zero, able to drop ≥2 log viral load at week-4 or showed no virus at the
time of half therapy completion, exhibited better response. The extension of therapy was more
beneficial for those non-responder who had <0.05 MIU/mL viral load at the end point of therapy
than those who had ≥0.05 MIU/mL at that stage. Conclusions: The viral load detection at early
stages of the therapy will be useful in clinical practice. Moreover, the patients with <0.05 MIU/
mL viral load at the end of therapy are suitable candidates for the therapy extension.