METABOLIC SYNDROME

GAMMA GLUTAMYLTRANSFERASE IN PATIENTS

Abstract

Objective: To determine the role of gamma glutamyltransferase as a biochemical
marker for the diagnosis of metabolic syndrome. Study Design: Cross sectional descriptive
study. Period: One year. Setting: Department of Medicine, Liaquat University Hospital
Hyderabad / Jamshoro. Methods: All the patients with metabolic syndrome visited at OPD /
admitted in the ward were further evaluated for serum gamma-glutamyltransferase level. The
data was analyzed in SPSS 16 and the frequency and percentage was calculated. Results:
During one year study period, total one hundred patients (23 males and 77 were females) with
metabolic syndrome were recruited and study for gamma glutamyl transferase level. The mean
age ±SD for overall population was 56.84±6.52 whereas it was 48.92±5.82 and 58.61±7.73
in male and female population respectively. The mean ± SD of systolic and diastolic blood
pressure (mmHg), triglycerides (mg/dl), high density lipoprotein pressure (mg/dl) and fasting
blood sugar (mg/dl) in overall population was 161.20 ± 16.74 and 95.60 ± 8.34, 176.38 ±
11.93, 29.44 ± 2.90 and 108.42± 6.25. The mean gamma glutamyl transferase level in overall
population was 86.75±7.74 while it was 84.83±5.32 and 89.52±6.84 in male and female
population respectively. The gamma-glutamyltransferase was raised in 75 patients of which
13 were males and 62 were females (p=0.02) and majority of patients were 50-59 year age
group (p <0.01). Conclusions: It is concluded that GGT is a good diagnostic tool in metabolic
syndrome with statistical significant results.