PRE-LABOUR RUPTURE OF MEMBRANES AT TERM;

COMPARISON OF EXPECTANT MANAGEMENT AND INDUCTION OF LABOUR USING MISOPROSTOL (PGE1)

Authors

  • BUSHA KHAN Sheikh Zayed Medical College/Hospital, Rahim Yar Khan.
  • NUZHAT RASHEED
  • BUSHRA MUKHTAR

DOI:

https://doi.org/10.29309/TPMJ/2013.20.05.1216

Keywords:

PROM,, intraamniotic infection,, misoprostol.

Abstract

Objective: To compare maternal and perinatal outcome in cases of PROM at term, following induction with vaginal
misoprostol (PGE1) to shorten the duration of labour with those managed expectantly. Design: Quasi Experimental study. Setting: The
study was carried out in department of obstetrics and gynecology labour room unit-1, Bahawal Victoria Hospital, Bahawalpur.
Population: Term pregnancies (37-42 wks) with PROM and cephalic alive fetuses. Methods: Sixty patients with confirmed diagnosis of
PROM were randomized into two groups i.e, A&B. Group A comprising 30 patients were induced with tab. Misoprostol 25 ug at 6 hrly
interval max of four doses and group B was managed expectantly for 24 hrs followed by induction with intravenous oxytocin. Outcome
Measures: Total duration of labour, mode of delivery, maternal infection rates and, APGAR score at 1 and 5 min. Results: It was found that
both groups had similar characteristics, but the misoprostol group had a significantly shorter time interval from PROM to delivery (18.9 vs
27.5 hours) i.e total duration of labour. Caesarean section rates were 20% in the misoprostol group and 30.7% in the other. There were no
differences between them regarding fetal well being, complications during labour and delivery and neonatal or postpartum maternal
morbidity. Within 24 hours, 44% of women had delivered in the expectant group against 73.3% in the misoprostol group. Conclusion:
Immediate labour induction with misoprostol in cases of term PROM shortens the total duration of labour, and the time of maternal
hospitalization without any maternal and perinatal outcomes disadvantages.

Author Biography

BUSHA KHAN, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan.

Senior Registrar, Unit-I
Obstetrics & Gynaecology Department,

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Published

2013-10-15