TYPE 2 DIABETES;

EFFICACY OF VITAMIN D SUPPLEMENTATION ON GLYCEMIC CONTROL IN TYPE 2 DIABETIC PATIENTS.

Abstract

Background: The data among vitamin D supplementation on glycemic control is
variable and contradictory in various clinical studies. Objectives: To determine the efficacy of vit
D supplementation on glycemic control in type 2 diabetic patients. Study Design: Case control
study. Setting: Private Clinical Set up of District, Rahim Yar Khan. Period: August to October
2016. Patients and methods: 100 cases of type 2 diabetes were randomly divided into group
A and group B each contained 50 patients .The cases in group A were treated with vitamin D3
at the dose of 50,000 units per week orally while cases in group B were treated with placebo
along with the standard doses of anti-diabetic drugs. The value of HbA1c and Vit D were
assayed pre and post treatment by high performance liquid chromatography. Results: There
was significant post treatment changes observed in vitamin D level in group A vs group B in
males 20.46±2.45 vs 15.16±1.47 (p= 0.001) and females 18.32±1.44 vs 13.95±2.48 (p= 0.09)
There was significant post treatment changes in HbA1c in males 6.65±0.12 vs 8.34±0.71 (p=
0.01) and in females 6.81±0.43 vs 8.04±0.71 (p= 0.03) in group A and group B respectively.
Similarly better improvement in vitamin D and HbA1c level was seen with respect to aged group
30-50 years and duration of diabetes less than 5 years. Conclusion: Vitamin D is deficient in our
population and its supplementation not only improves its own level but also glycemic control in
type 2 diabetic patients.