CHRONIC LIVER DISEASE

VITAMIN D DEFICIENCY IN THE PATIENTS

Abstract

Objective: The objective of this study to detect the vitamin D deficiency
associated to different risk factors in the patients with CLD. Study Design: Descriptive study.
Setting: MMC Mirpur Khas and LUH Jamshoro / Hyderabad. Period: Nov 2013 to Apr 2014.
Patients and Methods: All the cases with chronic liver disease and cirrhosis were included
in the study after diagnosis. All the patients with HCC, diabetes and with renal failure were
excluded from the study. Assessment of CLD causes was carried out by routine investigation,
ultrasound of abdomen and patient’s personal history. Furthermore to assessment of vitamin D
status, by measuring serum concentration level as 25(OH) of the vitamin D. Blood sample of all
the cases were send to the Diagnostic and research Laboratory of LUMHS. Results: Male were
found in the majority 60.0% and female 40.0%, with the mean age of (mean±SD=49.8±6.5).
Deficiency of the vitamin D was calculated according to different causes in according Vitamin
D classification as; (Mild class 20–31 ng/ml), (Moderate class 7–19 ng/ml) and (Severe class \7
ng/ml). In the mild class HBV infected patients 78.95% were most common. In moderate class
HBV +HCV infected patients were most common 52.94%. Patients with history of alcohol were
found in majority with severe deficiency of vitamin D 57.14%. Conclusion: In this study we
concluded that vitamin D deficiency increases with increases of liver severity, it’s mostly found
in the HCV infected and alcoholic liver disease, these patients should take vitamin D regularly,
and food which contains rich source of Vitamin D.