HYPERGLYCEMIA

CATHARANTHUS ROSEUS & NIGELLA SATIVA AMELIORATE IN ALLOXAN INDUCED DIABETIC RATS

Abstract

Objectives: To investigate blood glucose regulaitng effects of Catharanthus
Roseus (C.roseus) and Nigella sativa (N.sativa) in alloxan induced diabetic rats. Study Design:
Experimental study. Place and Duration: Animal house Isra University Hyderabad. From April
to Novermber 2013. Methodology: 50 male rats were housed at normal température, 12 hour
dark - light cycle with free access to chow and water. A single intraperitoneal bolus of alloxan
(120 mg/kg) was given to induce diabetes mellitus. Glimepiride, C. roseus and N. Sativa were
administered at doses of 0.1 mg/kg, 125 mg/kg and 50 g/kg respectively. Data was analyzed on
SPSS version 21.0. Significant P - value was defined at ≤ 0.05. Results: C.roseus ad N.sativa
showed blood glucose lowering potential but the effect was less when compared to glimepiride
(P = 0.001). However, C. roseus was more effective compared to N.sativa (P = 0.001) in
reducing blood glucose. Findings suggest that both C. roseus and N. sativa possess glucose
regulating potential. Conclusion: It is concluded that the C. roseus and N. sativa exert blood
glucose regulating effects in alloxan induced diabetic rat model.