BACTERIAL VAGINOSIS

COMPARISON OF VAGINAL METRONIDAZOLE WITH VAGINAL CLINDAMYCIN IN THE TREATMENT OF BACTERIAL VAGINOSIS

Abstract

Bacterial vaginosis is the most common vulvovaginal infection and represents
the 35% of all the infections occurring in women in the reproductive age. Serious forms of
can induce several complications such as spontaneous preterm labour and preterm birth, late
miscarriage and postpartum endometritis, PID, infertility, vaginal cuff infection and postabortal
sepsis. Objective: To compare the efficacy of vaginal metronidazole and vaginal clindamycin
in the treatment of bacterial vaginosis. Study Design: Interventional: Quasi experimental study.
Setting: Obstetrics outpatient department, Ghurki Trust Teaching Hospital, Lahore. Duration
of study: Six months i.e. from 01-01-2009 to 30-06-2009. Results: Mean age of patients was
found to be 24.33 years. In the 100 patients enrolled, no statistically significant difference was
found between Clindamycin 2% vaginal cream compared with metronidazole 0.75% vaginal
gel using Amsell’s criteria. Metronidazole has a failure rate of 13% while failure rate was 6% in
the clindamycin group. Conclusion: A 3 day regimen of clindamycin 2% vaginal cream was
as effective as 5 day regimen of metronidazole 0.75% vaginal gel in the treatment of bacterial
vaginosis.